HEMATOPOIESIS AND STEM CELLS Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells
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چکیده
• PGE2 signaling positively regulates hematopoietic stem cells both directly and via activation of a nonhematopoietic cell population. • EP4 is a major receptor for the PGE2-mediated regulation of hematopoietic stem and progenitor cells. Prostaglandin E2 (PGE2) regulates hematopoietic stem/progenitor cell (HSPC) activity. However, the receptor(s) responsible for PGE2 signaling remains unclear. Here, we identified EP4 as a receptor activated by PGE2 to regulate HSPCs. Knockdown of Ep4 in HSPCs reduced long-term reconstitution capacity, whereas an EP4-selective agonist
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